A curriculum vitae, or CV, are typically used by individuals who are searching for career opportunities in higher education, research, academic studies or a related field. Resumes are typically used by individuals who are searching for employment in other fields. What is major difference? A CV highlights experiences such as degrees earned, research completed, articles or books published, classes taught, presentations given, grants applied for and/or obtained and similar categories. Resumes highlight experiences related more to the various jobs the individual has held; the two documents can be used interchangeably.